Abstract
The recent hype surrounding the antimelanogenic properties of glutathione has resulted in physicians frequently administering it as a “wonder” drug for skin lightening and treatment of hyperpigmentation, especially in ethnic populations with darker skin tones. This phenomenon has seen a recent surge owing to aggressive marketing and capitalization of pharma-cosmeceutical companies. However, the unbridled and prodigal use of it, especially as a parenteral formulation, seems unjustified, given the lacunae in our knowledge about its antimelanogenic potential, limited clinical evidence favoring its role in skin lightening, and the statutory ban/advisory issued by certain federal agencies. Even though parenteral glutathione is approved only for severe liver disorders and for prevention of chemotherapy associated neurotoxicity, the lack of statutory laws governing the use of systemic glutathione in most countries has contributed to its unchecked use for skin lightening. The current clinical evidence of intravenous glutathione for skin lightening is limited to a single study with a dubious study design and apparently flawed analysis of results, casting doubt on the drug’s efficacy and reported adverse effects. Two studies evaluating oral/sublingual administration and one trial involving the use of topical glutathione reported good safety profile and appreciable but reversible results on skin tone. In this article, we shall review and discuss the current status of glutathione as a skin lightening agent and address the sundry unanswered queries regarding the dosage, duration of use and longevity of accrued effects based on clinical evidence and recent insights into its antimelanogenic mechanism.
It is a common knowledge that with time our skin begins to show signs of aging and in the process, it becomes pigmented, wrinkled and saggy. These skin conditions can also occur prematurely because of various other internal and external factors. So, it is not surprising that many of us often look for ways to rejuvenate our skin, get rid of excessive pigmentation, remove the wrinkles and fine lines, etc. With the advancement in cosmetology industry, there is no dearth of options to achieve this and one of those methods is the use of glutathione injection.
Is Glutathione Good For Skin Whitening?
Glutathione is a naturally occurring substance produced by our liver. This naturally present antioxidant is useful for performing a number of activities in our body such as building and repairing of body tissues, neutralizing free radicals, helping in immunity, acting as an anti-cancer agent, delaying the process of aging, etc. Over the years, the level of glutathione decreases in our body and when this happens, it accelerates the process of aging in our body. Because of this, people tend to turn to glutathione injections which help in maintaining their youthful look along with skin whitening. This external agent helps to increase the level of glutathione in our body.
Based on various studies and research, the general consensus is that glutathione injection’s results are mostly positive for skin whitening. Though taking this injection will provide results for a longer time, you will have to get booster shots in between in order to maintain the effects. These booster shots can either be in the form of injections or glutathione pills. The results of this procedure will be more effective if they are combined with other cosmetic treatments such as laser skin lightening.
Are Glutathione Injections Safe?
Yes, these injections are safe which is why it has become a popular way of rejuvenating your skin and bringing back your youthful radiance. Though it sounds wonderful to opt for glutathione injections as they quickly rejuvenate and whiten your skin, the side effects associated with it does not make it an ideal choice though.
Glutathione: Pills Or Injections
If you are wondering between glutathione injection vs pills, then the answer is that the injections are way more effective and long-lasting than glutathione pills. This does not mean that the glutathione pills do not provide results. Dermatologists will often prescribe injections rather than glutathione pills. The pills can be used as an occasional booster to maintain the effects of the injections.
What Is The Price Of Glutathione Injection In Pakistan?
The price of glutathione injection ranges from Rs 13,000 to Rs 40,000 per dose. Factors like quality, number of shots, and the maintenance dose required will change the cost of this procedure.
What Are The Common Side Effects Of Glutathione Injection?
Like every other cosmetic treatment out there, getting a shot of glutathione injection can also result in various side effects. Depending upon the dosage administered, the side effects can vary from mild to severe. This is why in order to avoid or minimize the severity of glutathione injection side effects, you should get it administered by a trained and experienced medical professional.
If in case the dosage administered is much higher than what is required, a patient can suffer serious side effects such as kidney failure or blood poisoning. Apart from this some of the other Glutathione injection side effects that can occur, if in case, the dosage given is more than 5 grams or more include:
- Nausea
- Skin rashes, hives or allergic reactions
- Diarrhea or other forms of stomach upset
- Loss of hair
- Breathing problem
- Chest pain
- Gain in weight
- Whitening of hair
- Steven Johnson’s syndrome
- Pain in breasts
- Toxic epidermal necrosis
- Numbness
- Eye disorder
- Aggravate symptoms of asthma
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